Inhibition of myeloperoxidase by benzoic acid hydrazides
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چکیده
منابع مشابه
Inhibition of myeloperoxidase by salicylhydroxamic acid.
Salicylhydroxamic acid inhibited the luminol-dependent chemiluminescence of human neutrophils stimulated by phorbol 12-myristate 13-acetate or the chemotactic peptide N-formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe). This compound had no inhibitory effect on the kinetics of O2.- generation or O2 uptake during the respiratory burst, but inhibited both the peroxidative activity of purified m...
متن کاملINHIBITION OF THE d-AMINO ACID OXIDASE BY BENZOIC ACID
Benzoic acid has been reported to inhibit the oxidation of succinic acid by muscle (l), the oxidation of butyric acid and crotonic acid by liver slices (2), and the oxidation of acetoacetic acid by kidney slices (3). It has also been reported to inhibit the oxygen uptake of liver and kidney slices, diaphragm, minced liver, kidney, and brain (4). In the present work it was found that benzoic aci...
متن کاملInhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides.
Tissue damage resulting from the extracellular production of HOCl (hypochlorous acid) by the MPO (myeloperoxidase)-hydrogen peroxide-chloride system of activated phagocytes is implicated as a key event in the progression of a number of human inflammatory diseases. Consequently, there is considerable interest in the development of therapeutically useful MPO inhibitors. Nitroxides are well establ...
متن کاملEffect of platinum(II) complexes of benzoic and 3-methoxybenzoic acid hydrazides on Saccharomyces cerevisiae.
The inhibitory effect of benzoic acid hydrazide (bah) and 3-methoxybenzoic acid hydrazide (mbah) on Saccharomyces cerevisiae strains has been compared to that of their platinum(II) complexes: cis-[Pt(mbah)2X2], cis-[Pt(NH3)(mbah)Cl2].0.5 H2O, cis-[Pt(mbah)2X2] and cis[Pt(NH3)(mbah)Cl2] (mean = Cl, Br = I), and cis-[Pt(NH3)2Cl2]. The minimal inhibitory concentrations for bah and mbah were 5000-2...
متن کاملInhibition of the alanine-alpha-oxoglutaric acid transaminase of pig-heart muscle by cyclic hydrazides.
8oNicotinic acid hydrazide (isoniazid) has antituberculous activity both in vivo and in vitro (Fox, 1951). In man its principal toxic effect, peripheral neuritis (Biehl & Vilter, 1954; Oestreicher, Dressler & Middlebrook, 1954), can be prevented by the concurrent administration of vitamin B. (pyridoxine) (Biehl & Vilter, 1954; Biehl & Nimitz, 1954). It is of interest to discover whether the spe...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1995
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj3080559